首页 / 院系成果 / 成果详情页

Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype 期刊论文

编号：

2A8F7F10E3E5625EC1631C498EDF6B38
作者：

Han, Peng#^[1,2,3]Lv, Wei#^[3]Xu, Zhe#^[4,5]Yu, Tianxi#^[6]Gao, Shan#^[7]Xiang, Xi^[1];Pan, Xiaoguang^[2];Zeng, Yuchen^[3];Havgaard, Jakob Hull^[2];Gorodkin, Jan^[2];Liang, Xue^[2];Wu, Shuang^[6];Tao, Huiying^[6];Sui, Xiaolong^[6];Wang, Wenting^[6];Dong, Wei^[3];Yang, Huanming^[3];Lin, Chunhua(林春华)*^[6]Regenberg, Birgitte*^[2]
语种：

英文
期刊：

CELL REPORTS ISSN：2639-1856 2025 年 44 卷 12 期 ; DEC 23
收录：
高质量科技期刊分级目录：

T2
摘要：

Megabase-sized extrachromosomal circular DNA with intact oncogenes (ecDNA) plays crucial roles in cancer. However, the impact of smaller (100 bp-1 Mb), more ubiquitous extrachromosomal circular DNA (eccDNA) on tumor pathology is unclear. We analyze eccDNA from 122 renal tumors and adjacent tissues, finding increased eccDNA in late-stage cancers, correlating with heightened patient mortality and copy-number amplification. Large eccDNAs are rare, and smaller eccDNAs predominate. The microRNA (miRNA) genes MIR107, MIR196a, MIR495, and MIR519 are recurrently found on eccDNA, almost exclusively in tumors, and patients with any one of these exhibited shorter progression-free survival. Synthetic eccDNAs with these MIR genes increase cancer cell proliferation in 786-O cells, suggesting oncogenic potential. Additionally, we found eccDNA carrying full protein-coding genes that are overexpressed in transcriptional analyses. Our findings suggest that small eccDNAs with miRNA genes are functional and contribute to the tumorigenesis of renal cell carcinoma.
推荐引用方式
GB/T 7714：

Han Peng,Lv Wei,Xu Zhe, et al. Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype [J].CELL REPORTS,2025,44(12).
APA：

Han Peng,Lv Wei,Xu Zhe,Yu Tianxi,&Regenberg Birgitte.(2025).Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype .CELL REPORTS,44(12).
MLA：

Han Peng, et al. "Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype" .CELL REPORTS 44,12(2025).
入库时间：

12/26/2025 10:47:28 AM
更新时间：

1/14/2026 9:34:34 PM
条目包含文件：

文件类型： , 文件大小：

正在加载全文

未找到全文

浏览次数：21  下载次数：0

分享到：

浏览次数：21

下载次数：0

打印次数：0