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Plasma glial fibrillary acidic protein as a mediator of amyloid-associated cognitive decline over 4-year follow-up in pre-dementia stages 期刊论文

编号：

5BCB164711233ADD4E73B1E82FDD0F74
作者：

Wei, Hongchun(魏红春)#^[1]Zhang, Chunhua^[2];Wen, Puyuan(温蒲圆)^[1]Kong, Min^[3];Ba, Maowen(巴茂文)*^[1,4]
语种：

英文
期刊：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING ISSN：2352-8729 2026 年 18 卷 1 期 ; MAR 13
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关键词：

amyloid beta cognitive decline hippocampal atrophy mediation analysis plasma glial fibrillary acidic protein pre-dementia
摘要：

INTRODUCTION The mechanism linking amyloid beta (A beta) pathology to cognitive decline in pre-dementia stages remains unclear.METHODS We performed mediation analysis in 223 non-demented adults (4-year follow-up) to assess plasma glial fibrillary acidic protein (GFAP), phosphorylated tau (p-tau)181, p-tau217, and peripheral inflammatory ratios as mediators of A beta (18F-florbetapir positron emission tomography)-related cognitive decline and hippocampal atrophy.RESULTS Plasma GFAP significantly mediated A beta-related multi-domain cognitive decline (accounting for 17.70% to 23.77% of the total effect) and hippocampal atrophy (specifically in the subgroup aged <= 70 years). Although both p-tau181 and p-tau217 were correlated with cognitive decline, they did not function as significant mediators of A beta's effects. Peripheral inflammatory ratios demonstrated no significant association with Alzheimer's disease (AD) progression.DISCUSSION Plasma GFAP is a key mediator and promising early biomarker for pre-dementia AD.
推荐引用方式
GB/T 7714：

Wei Hongchun,Zhang Chunhua,Wen Puyuan, et al. Plasma glial fibrillary acidic protein as a mediator of amyloid-associated cognitive decline over 4-year follow-up in pre-dementia stages [J].ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING,2026,18(1).
APA：

Wei Hongchun,Zhang Chunhua,Wen Puyuan,Kong Min,&Ba Maowen.(2026).Plasma glial fibrillary acidic protein as a mediator of amyloid-associated cognitive decline over 4-year follow-up in pre-dementia stages .ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING,18(1).
MLA：

Wei Hongchun, et al. "Plasma glial fibrillary acidic protein as a mediator of amyloid-associated cognitive decline over 4-year follow-up in pre-dementia stages" .ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING 18,1(2026).
入库时间：

3/31/2026 9:31:20 PM
更新时间：

3/31/2026 9:31:20 PM

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