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Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma 期刊论文

编号：

8c071b64-9851-4553-8499-47c0c01fa260
作者：

Jin, Lei(金磊)#^[1,2]Sturgis, Erich M.^[2,3]Zhang, Yang(张洋)#^[2,4]Huang, Zhigang(黄志刚)#^[2,4]Song, Xicheng(宋西成)^[2,5]Li, Chao(李超)^[2,6]Wei, Qingyi(魏庆义)^[3]Li, Guojun*^[2,3]
语种：

英文
期刊：

MOLECULAR CANCER ISSN：1476-4598 2013 年 12 卷 ; JUL 19
收录：
高质量科技期刊分级目录：

T1
关键词：

TNF-alpha Polymorphism HPV infection Oropharyngeal cancer Case-control study
摘要：

Background: Tumor necrosis factor alpha (TNF-alpha) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual susceptibility to HPV-associated oral squamous cell carcinoma (OSCC).
Methods: In this study we genotyped four common single nucleotide polymorphisms (SNPs) in the TNF-alpha promoter [ -308G > A(rs1800629), -857C > T (rs1799724), -863C > A (rs1800630), and -1031T > C (rs1799964)] and determined HPV16 serology in 325 OSCC cases and 335 matched controls and tumor HPV status in 176 squamous cell carcinomas of the oropharynx (SCCOP) patients. Univariate and multivariable logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
Results: We found that HPV16 seropositivity alone was associated with an increased risk of OSCC (OR, 3.1; 95% CI, 2.1-4.6), and such risk of HPV16-associated OSCC was modified by each SNP. Patients with both HPV16 seropositivity and variant genotypes for each SNP had the highest risk when using patients with HPV16 seronegativity and a wild-type genotype as a comparison group. Moreover, similar results were observed for the combined risk genotypes of four variants and all such significant associations were more pronounced in several subgroups, particularly in SCCOP patients and never smokers. Notably, the combined risk genotypes of four variants were also significantly associated with tumor HPV-positive SCCOP.
Conclusion: Taken together, these results suggest that TNF-alpha SNPs may individually or, more likely, jointly affect individual susceptibility to HPV16-associated OSCC, particularly SCCOP and never smokers. Validation of our findings is warranted.
推荐引用方式
GB/T 7714：

Jin Lei,Sturgis Erich M.,Zhang Yang, et al. Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma [J].MOLECULAR CANCER,2013,12.
APA：

Jin Lei,Sturgis Erich M.,Zhang Yang,Huang Zhigang,&Li Guojun.(2013).Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma .MOLECULAR CANCER,12.
MLA：

Jin Lei, et al. "Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma" .MOLECULAR CANCER 12(2013).
入库时间：

10/9/2020 12:32:07 PM
更新时间：

10/9/2020 12:32:07 PM
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