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Sodium Glycididazole Combined with Definitive Chemoradiotherapy for Patients with Esophageal Squamous Cell Carcinoma: A Multicenter Randomized Clinical Trial 期刊论文

编号：

C62C25340627AA6BD10DD7D6A45D787F
作者：

Li, Xiaoling#^[1]Zhao, Hanxi^[1];Xie, Peng^[2];Zhu, Wanqi^[3];Liu, Liping^[4];Wu, Peipei^[4];Sheng, Yanxing^[5];Wang, Chuandong^[6];Song, Yipeng(宋轶鹏)^[7]Meng, Xiangjiao^[1];Zhang, Jiandong^[8];Xing, Ligang*^[1]
语种：

英文
期刊：

PRECISION RADIATION ONCOLOGY ISSN：2398-7324 2026 年 ; 2026 FEB 25
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关键词：

concurrent chemoradiotherapy esophageal squamous cell carcinoma sodium glycididazole
摘要：

PURPOSE To evaluate the efficacy and safety of the radiosensitizer-sodium glycididazole (CMNa) combined with definitive concurrent chemoradiotherapy (CCRT) versus CCRT alone in patients with locally advanced esophageal squamous cell carcinoma (ESCC). METHODS Patients were enrolled and randomly assigned to receive CMNa plus CCRT (CMNa group) or CCRT alone (control group). CMNa (800 mg/m(2)) was administered three times per week during radiotherapy (1.8-2.0 Gy per fraction, total dose of 59.4-60.0 Gy). The primary endpoint was the objective response rate (ORR) and the secondary endpoint was the incidence of adverse events. RESULTS Sixty-six patients with ESCC were recruited from six medical centers between 2016 and 2018. The ORRs in the CMNa and control groups were 90.32% and 68.57%, respectively (chi(2) = 4.925, p = 0.0265). The proportions of patients with a complete response were 8/31 (25.81%) and 8/35 (22.86%) in the CMNa and control groups, respectively. The combination of CMNa and CCRT did not increase the incidence of acute or late adverse effects. CONCLUSION CMNa combined with CCRT improved the ORR in patients with ESCC compared with CCRT alone without increasing treatment-related toxicity. Trial Registration The protocol was registered at Clinicaltrials.gov (www.clinicaltrials.gov) (Clinical Trials ID: NCT02721563). Study Registration Date: March 29, 2016.
推荐引用方式
GB/T 7714：

Li Xiaoling,Zhao Hanxi,Xie Peng, et al. Sodium Glycididazole Combined with Definitive Chemoradiotherapy for Patients with Esophageal Squamous Cell Carcinoma: A Multicenter Randomized Clinical Trial [J].PRECISION RADIATION ONCOLOGY,2026.
APA：

Li Xiaoling,Zhao Hanxi,Xie Peng,Zhu Wanqi,&Xing Ligang.(2026).Sodium Glycididazole Combined with Definitive Chemoradiotherapy for Patients with Esophageal Squamous Cell Carcinoma: A Multicenter Randomized Clinical Trial .PRECISION RADIATION ONCOLOGY.
MLA：

Li Xiaoling, et al. "Sodium Glycididazole Combined with Definitive Chemoradiotherapy for Patients with Esophageal Squamous Cell Carcinoma: A Multicenter Randomized Clinical Trial" .PRECISION RADIATION ONCOLOGY(2026).
入库时间：

3/17/2026 9:29:51 PM
更新时间：

3/17/2026 9:29:51 PM

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