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Transfer of Fresh versus Frozen Embryos in Ovulatory Women 期刊论文 WOS高被引论文

编号：

F14FDF72E7E6EAE8ADF38E557A0D6A16
作者：

Shi, Yuhua#^[1,2]Sun, Yun#^[4,5]Hao, Cuifang(郝翠芳)#^[7]Zhang, Heping#^[23]Wei, Daimin#^[1,2]Zhang, Yunshan#^[8]Zhu, Yimin;Deng, Xiaohui^[3];Qi, Xiujuan^[11];Li, Hong^[13];Ma, Xiang^[14];Ren, Haiqin^[15];Wang, Yaqin^[16];Zhang, Dan^[9];Wang, Bo^[17];Liu, Fenghua^[18];Wu, Qiongfang^[20];Wang, Ze^[1,2];Bai, Haiyan^[21];Li, Yuan^[22];Zhou, Yi^[9,12];Sun, Mei^[1,2];Liu, Hong^[1,2];Li, Jing^[1,2];Zhang, Lin^[1,2];Chen, Xiaoli^[19];Zhang, Songying^[10];Sun, Xiaoxi^[6];Legro, Richard S.^[24];Chen, ZiJiang*^[1,2,4,5]
语种：

英文
期刊：

NEW ENGLAND JOURNAL OF MEDICINE ISSN：0028-4793 2018 年 378 卷 2 期 (126 - 136) ; JAN 11
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摘要：

BACKGROUND
Elective frozen-embryo transfer has been shown to result in a higher live-birth rate than fresh-embryo transfer among anovulatory women with the polycystic ovary syndrome. It is uncertain whether frozen-embryo transfer increases live-birth rates among ovulatory women with infertility.
METHODS
In this multicenter, randomized trial, we randomly assigned 2157 women who were undergoing their first in vitro fertilization cycle to undergo either freshembryo transfer or embryo cryopreservation followed by frozen-embryo transfer. Up to two cleavage-stage embryos were transferred in each participant. The primary outcome was a live birth after the first embryo transfer.
RESULTS
The live-birth rate did not differ significantly between the frozen-embryo group and the fresh-embryo group (48.7% and 50.2%, respectively; relative risk, 0.97; 95% confidence interval [CI], 0.89 to 1.06; P = 0.50). There were also no significant between-group differences in the rates of implantation, clinical pregnancy, overall pregnancy loss, and ongoing pregnancy. Frozen-embryo transfer resulted in a significantly lower risk of the ovarian hyperstimulation syndrome than fresh-embryo transfer (0.6% vs. 2.0%; relative risk, 0.32; 95% CI, 0.14 to 0.74; P = 0.005). The risks of obstetrical and neonatal complications and other adverse outcomes did not differ significantly between the two groups.
CONCLUSIONS
The live-birth rate did not differ significantly between fresh-embryo transfer and frozen-embryo transfer among ovulatory women with infertility, but frozen-embryo transfer resulted in a lower risk of the ovarian hyperstimulation syndrome.
推荐引用方式
GB/T 7714：

Shi Yuhua,Sun Yun,Hao Cuifang, et al. Transfer of Fresh versus Frozen Embryos in Ovulatory Women [J].NEW ENGLAND JOURNAL OF MEDICINE,2018,378(2):126-136.
APA：

Shi Yuhua,Sun Yun,Hao Cuifang,Zhang Heping,&Chen Zi-Jiang.(2018).Transfer of Fresh versus Frozen Embryos in Ovulatory Women .NEW ENGLAND JOURNAL OF MEDICINE,378(2):126-136.
MLA：

Shi Yuhua, et al. "Transfer of Fresh versus Frozen Embryos in Ovulatory Women" .NEW ENGLAND JOURNAL OF MEDICINE 378,2(2018):126-136.
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