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Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome 期刊论文 WOS高被引论文

编号：

de39f186-97be-4d84-98d3-01b389548fe1
作者：

Chen, ZiJiang(陈子江)#*^[1,2,3,4]Shi, Yuhua(石玉华)^[1,2]Sun, Yun(孙赟)^[3,4]Zhang, Bo^[5];Liang, Xiaoyan(梁晓燕)^[6]Cao, Yunxia(曹云霞)^[8]Yang, Jing^[9];Liu, Jiayin(刘嘉茵)^[10]Wei, Daimin(魏代敏)^[1,2]Weng, Ning^[11];Tian, Lifeng^[12];Hao, Cuifang(郝翠芳)^[13]Yang, Dongzi(杨冬梓)^[7]Zhou, Feng(周枫)^[14]Shi, Juanzi(师娟子)^[15]Xu, Yongle^[16];Li, Jing^[1,2];Yan, Junhao(颜军昊)^[1,2]Qin, Yingying(秦莹莹)^[1,2]Zhao, Han(赵涵)^[1,2]Zhang, Heping^[17]Legro, Richard S.^[18]
语种：

英文
期刊：

NEW ENGLAND JOURNAL OF MEDICINE ISSN：0028-4793 2016 年 375 卷 6 期 (523 - 533) ; AUG 11
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高质量科技期刊分级目录：

T1
摘要：

BACKGROUND
The transfer of fresh embryos is generally preferred over the transfer of frozen embryos for in vitro fertilization (IVF), but some evidence suggests that frozen-embryo transfer may improve the live-birth rate and lower the rates of the ovarian hyperstimulation syndrome and pregnancy complications in women with the polycystic ovary syndrome.
METHODS
In this multicenter trial, we randomly assigned 1508 infertile women with the polycystic ovary syndrome who were undergoing their first IVF cycle to undergo either fresh-embryo transfer or embryo cryopreservation followed by frozen-embryo transfer. After 3 days of embryo development, women underwent the transfer of up to two fresh or frozen embryos. The primary outcome was a live birth after the first embryo transfer.
RESULTS
Frozen-embryo transfer resulted in a higher frequency of live birth after the first transfer than did fresh-embryo transfer (49.3% vs. 42.0%), for a rate ratio of 1.17 (95% confidence interval [CI], 1.05 to 1.31; P = 0.004). Women who underwent frozen-embryo transfer also had a lower frequency of pregnancy loss (22.0% vs. 32.7%), for a rate ratio of 0.67 (95% CI, 0.54 to 0.83; P < 0.001), and of the ovarian hyperstimulation syndrome (1.3% vs. 7.1%), for a rate ratio of 0.19 (95% CI, 0.10 to 0.37; P < 0.001), but a higher frequency of preeclampsia (4.4% vs. 1.4%), for a rate ratio of 3.12 (95% CI, 1.26 to 7.73; P = 0.009). There were no significant between-group differences in rates of other pregnancy and neonatal complications. There were five neonatal deaths in the frozen-embryo group and none in the freshembryo group (P = 0.06).
CONCLUSIONS
Among infertile women with the polycystic ovary syndrome, frozen-embryo transfer was associated with a higher rate of live birth, a lower risk of the ovarian hyperstimulation syndrome, and a higher risk of preeclampsia after the first transfer than was fresh-embryo transfer. (Funded by the National Basic Research Program of China and others; ClinicalTrials.gov number, NCT01841528.)
推荐引用方式
GB/T 7714：

Chen Zi-Jiang,Shi Yuhua,Sun Yun, et al. Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome [J].NEW ENGLAND JOURNAL OF MEDICINE,2016,375(6):523-533.
APA：

Chen Zi-Jiang,Shi Yuhua,Sun Yun,Zhang Bo,&Legro Richard S..(2016).Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome .NEW ENGLAND JOURNAL OF MEDICINE,375(6):523-533.
MLA：

Chen Zi-Jiang, et al. "Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome" .NEW ENGLAND JOURNAL OF MEDICINE 375,6(2016):523-533.
入库时间：

10/9/2020 12:27:38 PM
更新时间：

10/9/2020 12:27:38 PM
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