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Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3 期刊论文

编号：

ec33024b-756f-427e-981b-562c0c6e7149
作者：

Chen, ZiJiang(陈子江)#*^[1,2]Zhao, Han(赵涵)#^[1,2]He, Lin(贺林)#^[3,4,5]Shi, Yuhua(石玉华)#^[1,2]Qin, Yingying(秦莹莹)^[1,2]Shi, Yongyong(师咏勇)*^[4]Li, Zhiqiang(李志强)^[4]You, Li^[1,2];Zhao, Junli^[6];Liu, Jiayin(刘嘉茵)^[7]Liang, Xiaoyan(梁晓燕)^[8]Zhao, Xiaoming(赵晓明)^[9]Zhao, Junzhao(赵军招)^[10]Sun, Yingpu(孙莹璞)^[11]Zhang, Bo^[12];Jiang, Hong;Zhao, Dongni^[13];Bian, Yuehong^[1,2];Gao, Xuan(高选)^[1,2]Geng, Ling^[1,2];Li, Yiran^[14,15];Zhu, Dongyi^[16];Sun, Xiuqin^[17];Xu, Jine(徐金娥)^[18]Hao, Cuifang(郝翠芳)^[19]Ren, Chune^[15];Zhang, Yajie^[20];Chen, Shiling(陈士岭)^[21]Zhang, Wei(张炜)^[22]Yang, Aijun^[23];Yan, Junhao(颜军昊)^[1,2]Li, Yuan^[1,2];Ma, Jinlong(马金龙)^[1,2]Zhao, Yueran(赵跃然)^[1,2]
语种：

英文
期刊：

NATURE GENETICS ISSN：1061-4036 2011 年 43 卷 1 期 (55 - U75) ; JAN
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摘要：

Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P-meta = 7.55 x 10(-21), odds ratio (OR) 0.71); 2p21 (rs13429458, P-meta = 1.73 x 10(-23), OR 0.67); and 9q33.3 (rs2479106, P-meta = 8.12 x 10(-19), OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.
推荐引用方式
GB/T 7714：

Chen Zi-Jiang,Zhao Han,He Lin, et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3 [J].NATURE GENETICS,2011,43(1):55-U75.
APA：

Chen Zi-Jiang,Zhao Han,He Lin,Shi Yuhua,&Zhao Yueran.(2011).Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3 .NATURE GENETICS,43(1):55-U75.
MLA：

Chen Zi-Jiang, et al. "Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3" .NATURE GENETICS 43,1(2011):55-U75.
入库时间：

10/9/2020 12:33:09 PM
更新时间：

10/9/2020 12:33:09 PM
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